STRUCTURAL BASIS FOR ACTIVATION AND NON-CANONICAL CATALYSIS OF THE RAP GTPASE ACTIVATING PROTEIN DOMAIN OF PLEXIN

Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

Plexins are cell surface receptors that bind semaphorins and transduce signals for regulating neuronal axon guidance and other processes.Plexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifically inactivates the Ras homolog Rap through an ill-defined non-canonical catalytic mechanism.The plexin GAP is a

read more

Regulations on investment breaks and exemptions from capital gains tax of natural persons in some European jurisdictions

In European countries diverse mechanisms of taxing KYO-DOPHILUS profits on capital gains of private persons are applicable.Among other things, they consist in diversified politics of concessions and tax exemptions, which then translates itself into the level of the effective fiscal burden of these incomes.In the article, the author describes tax br

read more